XIAFLEX for Dupuytren’s contracture

The only FDA-approved nonsurgical treatment for Dupuytren’s contracture when a "cord" can be felt.

What is XIAFLEX®?

XIAFLEX® is an FDA-approved nonsurgical injectable treatment for adults with Dupuytren’s contracture when a “cord” can be felt. XIAFLEX® should be injected by a healthcare provider experienced in injection procedures of the hand and in treating people with Dupuytren’s contracture.

How can XIAFLEX® help?

XIAFLEX®, along with a finger extension procedure, may help straighten or nearly straighten finger(s) affected by Dupuytren’s contracture and may improve range of motion after up to 3 injections.

XIAFLEX® may help:

• Contractures ranging from less severe to more severe*
• Multiple contractures (up to 2 cords in 1 hand during the same office visit)
• Contractures that have come back

Who can get XIAFLEX®?

XIAFLEX® is indicated for adults with Dupuytren’s contracture who have a collagen “cord” that can be felt. It is estimated that more than 190,000 adult patients with Dupuytren’s contracture have been prescribed XIAFLEX®† since it was approved by the FDA in 2010.

One way to self-test for Dupuytren’s contracture, or to assess the progression of your Dupuytren’s contracture, is to take the Tabletop Test. If you can’t lay your hand flat against a surface (like a tabletop), you may have Dupuytren’s contracture.

Dupuytren’s contracture is a chronic condition, no matter what treatment option you use. If your contracture returns after treatment, your Hand Specialist will let you know if XIAFLEX® may be used again.

What can i expect at mY XIAFLEX® Procedure?

• The Hand Specialist will inject XIAFLEX® directly into the cord that is causing your finger(s) to bend. If you have 2 contractures on the same hand, your Hand Specialist may give you 2 injections during the same visit. General anesthesia is not recommended before XIAFLEX® injections.
• Your hand will be bandaged, and you will be advised to keep your hand elevated until bedtime. Limit the movement of your treated finger(s), and do not manually bend or straighten the treated finger(s) yourself. You may see swelling or bruising after the injection.
• Plan to have someone drive you home from the procedure

• Approximately 1 to 3 days after the injection procedure, if you still have a cord, a Hand Specialist may try to extend the treated finger(s) and “break” the cord to help straighten your finger(s). Your doctor may use a local anesthetic for this procedure.
• It’s important to wear the splint provided by your Hand Specialist at bedtime nightly for up to 4 months and do finger exercises several times a day for several months.
• Follow the Hand Specialist’s instructions on when you can start doing normal activities with your injected hand.

• At the 30-day follow-up appointment, the Hand Specialist will look at your hand. Depending on the results or if you still have a cord, they may suggest additional injections and finger extension procedures (up to 3 times per cord, approximately 4 weeks apart)

What are the side effects of XIAFLEX®?

XIAFLEX® can cause serious side effects such as tendon rupture, ligament damage, and/or nerve injury or other serious injury of the hand; hypersensitivity reactions, including anaphylaxis; fainting, and increased chance of bleeding in certain cases.

AT-HOME FINGER EXERCISE GUIDE

After treatment with XIAFLEX®, your doctor will prescribe finger exercises for you to perform at home. Do the finger exercises each day as instructed by your doctor.

Examples of at-home finger exercises:

Lay your hand flat on the table. Raise each finger up one at a time and hold for 5 seconds; repeat 10 times. Repeat this exercise 4 times a day.

Lay your hand flat on the table. Move each finger from side to side (like a windshield wiper) one at a time; repeat 10 times. Repeat this exercise 4 times a day.

Bend only the top 2 joints of all fingers, keeping your knuckles straight. Arch your knuckles back 10 times in a row. Repeat this exercise 4 times a day.

Use the unaffected hand to gently straighten the affected finger 10 times, holding for 5 to 10 seconds. Repeat this exercise 4 times a day.